Pope Leo embarked on an important journey early Friday, departing from Rome’s Fiumicino Airport as he heads to Uruguay for the country’s first papal visit since 1988. His expected arrival time is 4:30 p.m. local time (2:30 p.m. ET).
Uruguay: A Secular Nation
Uruguay is recognized as the most secular country in South America, where attendance at Mass is relatively low. The country has made headlines for its progressive social policies, being the first globally to legalize marijuana for recreational use, as well as the second in Latin America to decriminalize abortion.
In a significant development in October 2025, Uruguay became the first nation in the region to pass legislation permitting assisted dying, despite facing considerable opposition from the Catholic Church.
Papal Visit to Argentina
Following his engagement in Uruguay, Pope Leo’s itinerary includes a three-day visit to Argentina, where he is set to meet with President Javier Milei, a political figure known for his ties to former U.S. President Donald Trump. This will mark the first papal visit to Argentina since Pope John Paul II’s historic trip in 1987.
It is worth noting that Pope Leo’s predecessor, Pope Francis, who hails from Argentina, declined multiple invitations to revisit his home country.
Upcoming Journey to Peru
During his upcoming six-day stay in Peru, Pope Leo is anticipated to encounter significant crowds, as he is a well-regarded figure in the nation. His visit will begin in the capital city of Lima, before proceeding to Chiclayo, where he served as bishop from 2014 until assuming his Vatican role in 2023.
Pope Leo will also engage in several high-altitude visits within the Peruvian Andes, as part of his itinerary.
Health and Readiness for the Journey
Recently, Pope Leo received treatment for lung adenocarcinoma, the most prevalent form of lung cancer. Medical reports indicate that his condition is localized, and he will not require additional treatment during his travels. Vatican spokesperson Matteo Bruni has confirmed that the Pope has made a recovery sufficient to proceed without further medical interventions.
At a press briefing, Maria Montserrat Alvarado, the Vatican’s new communications chief, emphasized that Pope Leo expresses gratitude for the health concerns raised by others, noting his enthusiasm about the upcoming journey. “He was ‘so excited’ to make the trip,” she stated.
